Synthesis and anti-BVDV activity of novel δ-sultones in vitro: implications for HCV therapies.

Abstract:

:In this study we report the synthesis and activity against bovine viral diarrhea virus (BVDV) of a novel series of bicycle δ-sultones containing γ-lactones. BVDV is responsible for major losses in cattle. Some of the synthesized δ-sultones showed pronounced anti-BVDV activity with EC50 values of 0.12-1.0μM and no significant cytotoxicity. Among them, the ortho bromosubstituted derivative 4f (EC50=0.12μM) showed better antiviral activity than other derivatives and was 10 fold more that of than positive control ribavirin (EC50=1.3μM). BVDV is also considered to be a valuable surrogate for the hepatitis C virus (HCV) in antiviral drug studies. The above results provided a novel candidate for the development of anti-HCV agents.

journal_name

Bioorg Med Chem Lett

authors

Xu HW,Zhao LJ,Liu HF,Zhao D,Luo J,Xie XP,Liu WS,Zheng JX,Dai GF,Liu HM,Liu LH,Liang YB

doi

10.1016/j.bmcl.2014.03.012

subject

Has Abstract

pub_date

2014-05-15 00:00:00

pages

2388-91

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00228-5

journal_volume

24

pub_type

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