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New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-fused and hetero-fused systems.

Abstract：

:The synthesis and the SAR of a new series of potent and selective dopamine D(3) receptor antagonists is reported. The new scaffolds of the [g]-fused and the hetero-fused tricyclic benzazepine are here reported together with their pharmacokinetic profile.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Micheli F,Bonanomi G,Braggio S,Capelli AM,Damiani F,Di Fabio R,Donati D,Gentile G,Hamprecht D,Perini O,Petrone M,Tedesco G,Terreni S,Worby A,Heidbreder C

doi

10.1016/j.bmcl.2007.12.042

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

908-12

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01500-4

journal_volume

18

pub_type

杂志文章

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