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Flavonoids: structural requirements for antiproliferative activity on breast cancer cells.

Abstract：

:Several classes of flavonoids (flavones, flavanones, 2'-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure-activity relationships of these compounds were discussed. 2'-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Pouget C,Lauthier F,Simon A,Fagnere C,Basly JP,Delage C,Chulia AJ

doi

10.1016/s0960-894x(01)00617-5

subject

Has Abstract

pub_date

2001-12-17 00:00:00

pages

3095-7

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960894X01006175

journal_volume

11

pub_type

杂志文章

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