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Phosphonium-ammonium-based di-cationic ionic liquids as antibacterial over the ESKAPE group.

Abstract：

:Emergence of antibioresistance is currently a major threat of public health worldwide. Hence there is an urge need of finding new antibacterial material. Herein, we report a simple and eco-friendly method to synthesize homo and heterodicationic ionic liquids based on quaternary phosphonium and ammonium salt. In order to investigate the structure activity relationship (SAR) we measured the MICs of a series of 16 derivatives with structural variations (nature of cations and counter-ions, size of linker and alkyl side chains as well as structural symmetry) over a range of Gram-positive and Gram-negative bacterial strains from the ESKAPE group. Some of the tested structures exhibit high antimicrobial activities (MIC = 0.5 mg/L) and are active over a wide range of bacteria from Gram-positive to Gram-negative. Overall, these results reveal the strong potential of di-cationic derivatives as antibacterial agents and the determination of activities from structural features gives decisive information for future synthesis of such di-cationic structures for biocidal purpose.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Brunel F,Lautard C,Garzino F,Raimundo JM,Bolla JM,Camplo M

doi

10.1016/j.bmcl.2020.127389

subject

Has Abstract

pub_date

2020-09-15 00:00:00

pages

127389

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(20)30500-X

journal_volume

30

pub_type

杂志文章

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