Targeting tyrosine kinase: Development of acridone - pyrrole - oxindole hybrids against human breast cancer.

Abstract:

:Based on the molecular modelling studies, a rational modification of the lead molecule was made to develop highly potent compounds showing anti-cancer activity against human breast cancer cell lines MCF 7, MDA-MB-468 and T-47D. The most potent compounds have Log P and total polar surface area 4.4-5.4 and 59.8 Å, respectively and they also exhibited promising ADME profile.

journal_name

Bioorg Med Chem Lett

authors

Kaur M,Singh P

doi

10.1016/j.bmcl.2018.11.021

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

32-35

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(18)30885-0

journal_volume

29

pub_type

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