Topological estimation of electronic absorption bands of arene absorption spectra as a tool for modeling their toxicity and environmental pollution.

Abstract:

:A novel application of distance-based topological indices : Wiener (W)-, Szeged (Sz)-, Padmakar-Ivan (PI)-, and Sadhana (Sd)-indices in modeling electronic absorption bands of arene absorption spectra has been described. It is demonstrated that all these indices correlate linearly with the logarithm of beta and para electronic absorption bands in several series of arene systems. The results have shown that our methodology is best suited for the estimation--lnlambda(beta), while comparatively less significant results are obtained in case of the estimation of lnlambda(p). The statistical analysis of the data have shown that PI index gives better results for modeling lnlambda(beta); while Sz index proved better for modeling lnlambda(p). The results are critically discussed on the basis of regression parameters and quality of correlation. Such a study will be useful as a tool for modeling toxicity of arene system as well as their environmental pollution.

journal_name

Bioorg Med Chem Lett

authors

Khadikar PV,Singh S,Jaiswal M,Mandloi D

doi

10.1016/j.bmcl.2004.06.094

subject

Has Abstract

pub_date

2004-09-20 00:00:00

pages

4795-801

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(04)00885-6

journal_volume

14

pub_type

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