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Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.

Abstract：

:A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Beck JP,Curry MA,Chorvat RJ,Fitzgerald LW,Gilligan PJ,Zaczek R,Trainor GL

doi

10.1016/s0960-894x(99)00159-6

subject

Has Abstract

pub_date

1999-04-19 00:00:00

pages

1185-8

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(99)00159-6

journal_volume

9

pub_type

杂志文章

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