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Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors.

Abstract：

:This article describes the syntheses and SAR of a series of imidazolopyrimidine derivatives, which are evaluated as inhibitors of PI3-Kinase (PI3K) and mTOR. These compounds were found to be ATP competitive with good tumor cell growth inhibition, and suppression of pathway specific biomakers such as phosphorylation of Akt at T308.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Venkatesan AM,Dehnhardt CM,Chen Z,Santos ED,Dos Santos O,Bursavich M,Gilbert AM,Ellingboe JW,Ayral-Kaloustian S,Khafizova G,Brooijmans N,Mallon R,Hollander I,Feldberg L,Lucas J,Yu K,Gibbons J,Abraham R,Mansour TS

doi

10.1016/j.bmcl.2009.11.057

subject

Has Abstract

pub_date

2010-01-15 00:00:00

pages

653-6

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01627-8

journal_volume

20

pub_type

杂志文章

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