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Selective oxidation of 5-hydroxymethylcytosine with micelle incarcerated oxidants to determine it at single base resolution.

Abstract：

:5-Methylcytosine (5mC) is oxidized by ten-eleven translocation (TET) enzymes. This process followed by thymine DNA glycosylase is proposed to be the mechanism for methylcytosine demethylation. 5-Hydroxymethylcytosine (5hmC) is one of the most important key oxidative metabolites in the demethylation process, and therefore, simple and accurate method to determine 5hmC at single base resolution is desired. In the present study, we developed a mild catalytic oxidation of 5-hmC using micelle incarcerated oxidants that enables to determine the position of 5hmC at single base resolution.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Fukuzawa S,Tachibana K,Tajima S,Suetake I

doi

10.1016/j.bmcl.2015.11.017

subject

Has Abstract

pub_date

2015-12-15 00:00:00

pages

5667-71

issue

24

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30226-2

journal_volume

25

pub_type

杂志文章

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