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Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives.

Abstract：

:New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

You YJ,Kim Y,Nam NH,Ahn BZ

doi

10.1016/s0960-894x(03)00724-8

subject

Has Abstract

pub_date

2003-10-06 00:00:00

pages

3137-40

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960894X03007248

journal_volume

13

pub_type

杂志文章

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