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Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.

Abstract：

:Biflorin 1 is a biologically active quinone, isolated from Capraria biflora. Five new biflorin-based nitrogen derivatives were synthesized, of which two were mixtures of (E)- and (Z)- isomers: (Z)-2a, (Z)-2b, (Z)-3a, (Z)- and (E)-3b, (Z)- and (E)-3c. The antibacterial activity was investigated using the microdilution method for determining the minimum inhibitory concentration (MIC) against six bacterial strains. Tests have shown that these derivatives have potential against all bacterial strains. The cytotoxic activity was also evaluated against three strains of cancer cells, but none of the derivatives showed activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

da S Souza LG,Almeida MCS,Lemos TLG,Ribeiro PRV,de Brito ES,Silva VLM,Silva AMS,Braz-Filho R,Costa JGM,Rodrigues FFG,Barreto FS,de Moraes MO

doi

10.1016/j.bmcl.2015.11.095

subject

Has Abstract

pub_date

2016-01-15 00:00:00

pages

435-439

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30303-6

journal_volume

26

pub_type

杂志文章

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