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A comparison of the alpha-helix forming propensities and hydrogen bonding properties of serine phosphate and alpha-amino-gamma-phosphonobutyric acid.

Abstract：

:The ability of serine phosphate (SerP) or alpha-amino-gamma-phosphonobutyric acid (AbuP) and arginine to form a salt bridge between their side chains appears to be much greater when they are spaced i/i+4 than when they are spaced i/i+3. The side chain-side chain interaction between SerP/Arg and AbuP/Arg, positioned i/i+4, contribute 0.45 and 0.62 kcal mol(-1), respectively, toward stabilizing the alpha-helical conformation of a peptide.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Liehr S,Chenault HK

doi

10.1016/s0960-894x(99)00469-2

subject

Has Abstract

pub_date

1999-09-20 00:00:00

pages

2759-62

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960894X99004692

journal_volume

9

pub_type

杂志文章

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