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Identification of novel PPARalpha ligands by the structural modification of a PPARgamma ligand.

Abstract：

:To develop novel PPARalpha ligands, we designed and synthesized several 3-{3-[2-(nonylpyridin-2-ylamino)ethoxy]phenyl}propanoic acid derivatives. Compound 10, the meta isomer of a PPARgamma agonist 1, has been identified as a PPARalpha ligand. The introduction of methyl and ethyl groups at the C-2 position of the propanoic acid of 10 further improved the PPARalpha-binding potency.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Usui S,Fujieda H,Suzuki T,Yoshida N,Nakagawa H,Miyata N

doi

10.1016/j.bmcl.2006.03.031

subject

Has Abstract

pub_date

2006-06-15 00:00:00

pages

3249-54

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00326-X

journal_volume

16

pub_type

杂志文章

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