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Cyclonatsudamine A, a new vasodilator cyclic peptide from Citrus natsudaidai.

Abstract：

:A new cyclic heptapeptide, cyclonatsudamine A (1), cyclo (-Gly-Tyr-Leu-Leu-Pro-Pro-Ser-), has been isolated from the peels of Citrus natsudaidai and the structure was elucidated by 2D NMR analysis and chemical degradation. Cyclonatsudamine A (1) relaxed norepinephrine-induced contractions of rat aorta, which may be mediated through the increased release of NO from endothelial cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Morita H,Enomoto M,Hirasawa Y,Iizuka T,Ogawa K,Kawahara N,Goda Y,Matsumoto T,Takeya K

doi

10.1016/j.bmcl.2007.07.036

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

5410-3

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00851-7

journal_volume

17

pub_type

杂志文章

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