Abstract:
:A prodrug based on a known antibacterial compound is reported to target Staphylococcus aureus and Escherichia coli under reductive conditions. The prodrug was prepared by masking the N-terminus and side chain amines of a component lysine residue as 4-nitrobenzyl carbamates. Activation to liberate the antibacterial was demonstrated on treatment with a model reductant, tin(II) chloride. The bioactivity of 1 was confirmed in antibacterial susceptibility assays whereas prodrug 2 was inactive.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Yeoh YQ,Horsley JR,Polyak SW,Abell ADdoi
10.1016/j.bmcl.2020.127140subject
Has Abstractpub_date
2020-06-01 00:00:00pages
127140issue
11eissn
0960-894Xissn
1464-3405pii
S0960-894X(20)30233-Xjournal_volume
30pub_type
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