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Progress in discovery of small-molecule modulators of protein-protein interactions via fragment screening.

Abstract：

:Protein-protein interactions (PPIs) present a formidable challenge to medicinal chemistry. The extended and open nature of many binding sites at protein interfaces has made it difficult to find useful chemical matter by traditional screening methods using standard screening libraries. This Digest focuses on the progress that has been made in discovering small-molecule modulators for a diverse selection of PPI targets using fragment screening and highlights the utility of this strategy in this context.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Magee TV

doi

10.1016/j.bmcl.2015.04.089

subject

Has Abstract

pub_date

2015-06-15 00:00:00

pages

2461-8

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00421-7

journal_volume

25

pub_type

杂志文章,评审

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