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A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents.

Abstract：

:A simple and rapid NMR method is described to determine the logP of pharmaceutical agents. This method is highly versatile and efficient, because it does not require the use of deuterated solvents or the addition of any internal/external standards to the sample. We demonstrate that logP can be accurately measured using NMR for pharmaceutical agents with known logP values. Our proposed method is made possible by the combination of state-of-the-art NMR techniques including the solvent concentration reference and robust solvent suppressions.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Mo H,Balko KM,Colby DA

doi

10.1016/j.bmcl.2010.08.145

subject

Has Abstract

pub_date

2010-11-15 00:00:00

pages

6712-5

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01291-6

journal_volume

20

pub_type

杂志文章

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