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Serendipitous discovery of aryl boronic acids as β-lactamase inhibitors.

Abstract：

:High throughput screening for β-lactamase inhibitors afforded biphenyl hits such as 1. Hit confirmation and X-ray soaking experiments with Pseudomonas Aeruginosa AmpC enzyme led to the identification of an aryl boronic acid-serine complex 4, which was formed from phenyl boronic acid 8 (an impurity in compound 1) and ethylene glycol (the cryoprotectant in the soaking experiment).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yang SW,Pan J,Root Y,Scapin G,Xiao L,Su J

doi

10.1016/j.bmcl.2019.126795

subject

Has Abstract

pub_date

2020-01-15 00:00:00

pages

126795

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(19)30760-7

journal_volume

30

pub_type

杂志文章

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