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Cu2+-labeled dansyl compounds as fluorescent and PET probes for imaging apoptosis.

Abstract：

:Compound DNSTT-Cu2+, a novel chelate of Cu2+ with DOTA conjugated to a fluorescent dansyl fragment, is developed for imaging cell apoptosis. Apoptotic U-87MG cells could be selectively visualized by the fluorescence of DNSTT-Cu2+ from cytoplasm of cells, confirmed by the fluorescence of apoptosis cells co-labeled with Alexa Fluor 568-labeled annexin V, a conventional probe for selectively labeling membranes of apoptosis cells. A radioactive 64Cu2+ analog, DNSTT-64Cu2+, was easily synthesized, providing a potential PET probe for imaging apoptosis in vivo.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Han J,Wang X,Yu M

doi

10.1016/j.bmcl.2016.09.057

subject

Has Abstract

pub_date

2016-11-15 00:00:00

pages

5594-5596

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30999-4

journal_volume

26

pub_type

杂志文章

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