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RNA aptazyme-tethered large gold nanoparticles for on-the-spot sensing of the aptazyme ligand.

Abstract：

:A single-step sensing system was developed to visually detect ligands of a cleavase-like RNA aptazyme at room temperature using aptazyme-tethered gold nanoparticles, the electrosteric stability of which was adjusted by increasing their diameter. In this system, the ligand induces self-cleavage of the aptazyme on gold nanoparticles to decrease the electrosteric stability of the gold nanoparticles, which causes them to visibly aggregate. In comparison to a previous multi-step system using aptazymes and gold nanoparticles separately, the present system requires only single handling and no special equipment, making it more suitable for on-the-spot sensing.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ogawa A

doi

10.1016/j.bmcl.2010.11.048

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

155-9

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01660-4

journal_volume

21

pub_type

杂志文章

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