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The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists.

Abstract：

:Bipiperidine amide 1 has been identified as a CC chemokine receptor 3 (CCR3) antagonist. Optimization of its structure-activity relationship has resulted in the identification of cis (R,R)-4-[(3,4-dichlorophenyl)methyl]-3-hydroxymethyl-1'(6-quinolinylcarbonyl)-1,4'-bipiperidine 14n, which exhibits potent receptor affinity and inhibition of both calcium flux and eosinophil chemotaxis.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ting PC,Lee JF,Wu J,Umland SP,Aslanian R,Cao J,Dong Y,Garlisi CG,Gilbert EJ,Huang Y,Jakway J,Kelly J,Liu Z,McCombie S,Shah H,Tian F,Wan Y,Shih NY

doi

10.1016/j.bmcl.2005.01.016

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

1375-8

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00059-4

journal_volume

15

pub_type

杂志文章

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