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Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles.

Abstract：

:A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sharon A,Pratap R,Tiwari P,Srivastava A,Maulik PR,Ram VJ

doi

10.1016/j.bmcl.2005.02.060

subject

Has Abstract

pub_date

2005-04-15 00:00:00

pages

2115-7

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00245-3

journal_volume

15

pub_type

杂志文章

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