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Dinucleotide cap analogue affinity resins for purification of proteins that specifically recognize the 5' end of mRNA.

Abstract：

:Here we present first dinucleotide affinity resins for purification of proteins that specifically recognize the 5' end of mRNA. Constructed resins possess either a naturally occurring mono- or trimethylated cap or their analogues resistant towards enzymatic degradation, bearing a CH(2) bridge between β and γ position of the 5',5'-triphosphate chain. All cap analogues were attached to a polymer support (EAH-Sepharose) through the carboxylic group that had been generated by derivatization of the 2',3'-cis diol of the second nucleotide in the cap structure with levulinic acid.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jankowska-Anyszka M,Piecyk K

doi

10.1016/j.bmcl.2011.08.026

subject

Has Abstract

pub_date

2011-10-15 00:00:00

pages

6131-4

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01111-5

journal_volume

21

pub_type

杂志文章

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