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Synthesis and biological evaluation of didemnin photoaffinity analogues.

Abstract：

:The synthesis of four benzophenone-containing analogues of the antiproliferative natural product didemnin B is presented. In vitro protein biosynthesis inhibition potency and antitumor activity were evaluated. The results indicate that all four analogues are biologically active and could serve as photoaffinity reagents for the study of receptor-binding interactions of didemnins. These analogues could also be useful in studying antitumor effects of didemnins.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Vera MD,Pfizenmayer AJ,Ding X,Ahuja D,Toogood PL,Joullié MM

doi

10.1016/s0960-894x(01)00339-0

subject

Has Abstract

pub_date

2001-07-23 00:00:00

pages

1871-4

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960894X01003390

journal_volume

11

pub_type

杂志文章

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