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Identification of 2-aminooxazole amides as acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) inhibitors through scaffold hopping strategy.

Abstract：

:A scaffold hopping strategy was successfully applied in discovering 2-aminooxazole amides as potent DGAT1 inhibitors for the treatment of dyslipidemia. Further optimization in potency and PK properties resulted in a lead series with oral in vivo efficacy in a mouse postprandial triglyceridemia (PPTG) assay.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kim HM,Smith MD,Kim JH,Caplen MA,Chan TY,McKittrick BA,Cook JA,van Heek M,Lachowicz J

doi

10.1016/j.bmcl.2013.09.048

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

6410-4

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)01122-0

journal_volume

23

pub_type

杂志文章

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