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Rapid solid-phase synthesis of DNA-binding pyrrole-imidazole polyamides.

Abstract：

:Pyrrole-imidazole polyamides can be synthesized to target predetermined sequences of DNA with nanomolar affinity and high specificity, and have been shown to modulate gene transcription both in vitro and in vivo. To make polyamides more readily available to biological laboratories, we have developed a rapid solid-phase synthesis based on azabenzotriazole (OAt) activation that decreases synthesis time 60% compared to standard benzotriazole (OBt) techniques, without loss of yield or purity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Krutzik PO,Chamberlin AR

doi

10.1016/s0960-894x(02)00359-1

subject

Has Abstract

pub_date

2002-08-19 00:00:00

pages

2129-32

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960894X02003591

journal_volume

12

pub_type

杂志文章

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