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Synthesis and properties of cationic 2'-O-[N-(4-aminobutyl)carbamoyl] modified oligonucleotides.

Abstract：

:2'-O-[N-(4-Aminobutylcarbamoyl)]uridine (U(abcm)) was synthesized and incorporated into oligonucleotides. The oligonucleotides incorporating U(abcm) formed more stable duplexes with their complementary and mismatched RNAs than those containing 2'-O-carbamoyluridine (U(cm)). The stability of duplex with a U(abcm)-rG base pair showed higher thermostability than the duplex having unmodified U-rG base pair. The U(abcm) residue showed enhanced resistance to snake venome phosphodiesterase.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Seio K,Tokugawa M,Kanamori T,Tsunoda H,Ohkubo A,Sekine M

doi

10.1016/j.bmcl.2012.02.012

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

2470-3

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00195-3

journal_volume

22

pub_type

杂志文章

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