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Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel.

Abstract：

:A collection of aryl sulfonamido indanes based on the lead compound 1 was synthesized and evaluated for Kv1.5 inhibitory activity. Kv1.5 inhibitors have the potential to be atrium-selective agents for treatment of atrial fibrillation. (1R,2R)-1 has an IC(50) of 0.033microM against Kv1.5 and is selective against other cardiac ion channels, including hERG.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Gross MF,Beaudoin S,McNaughton-Smith G,Amato GS,Castle NA,Huang C,Zou A,Yu W

doi

10.1016/j.bmcl.2007.02.052

subject

Has Abstract

pub_date

2007-05-15 00:00:00

pages

2849-53

issue

10

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00249-1

journal_volume

17

pub_type

杂志文章

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