Abstract:
:The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Ringom R,Axen E,Uppenberg J,Lundbäck T,Rondahl L,Barf Tdoi
10.1016/j.bmcl.2004.06.058subject
Has Abstractpub_date
2004-09-06 00:00:00pages
4449-52issue
17eissn
0960-894Xissn
1464-3405pii
S0960-894X(04)00832-7journal_volume
14pub_type
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