Abstract:
:4-Deacetoxyagosterol A was synthesized from ergosterol by utilizing reductive regioselective epoxy cleavage as a key reaction. This synthesized congener of agosterol A, a spongean MDR-modulator. showed similar MDR-modulating activity against KB CV-60 cells overexpressing MRP.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Murakami N,Sugimoto M,Morita M,Akiyama S,Kobayashi Mdoi
10.1016/s0960-894x(00)00502-3subject
Has Abstractpub_date
2000-11-20 00:00:00pages
2521-4issue
22eissn
0960-894Xissn
1464-3405pii
S0960894X00005023journal_volume
10pub_type
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