Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods.

Abstract:

:New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.

journal_name

Bioorg Med Chem Lett

authors

Semple G,Andersson BM,Chhajlani V,Georgsson J,Johansson MJ,Rosenquist A,Swanson L

doi

10.1016/s0960-894x(03)00033-7

subject

Has Abstract

pub_date

2003-03-24 00:00:00

pages

1141-5

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960894X03000337

journal_volume

13

pub_type

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