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A method for the synthesis of an oseltamivir PET tracer.

Abstract：

:A protocol applicable for the synthesis of an oseltamivir positron emission tomography (PET) tracer was developed. Acetylation of amine 3 with CH(3)COCl, followed by deprotection and aqueous workup, produced oseltamivir 4 from 3 within 10 min. The obtained 4 was sufficiently pure for PET studies. This method can be extended to PET tracer synthesis using CH(3)(11)COCl.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Morita M,Sone T,Yamatsugu K,Sohtome Y,Matsunaga S,Kanai M,Watanabe Y,Shibasaki M

doi

10.1016/j.bmcl.2007.11.079

subject

Has Abstract

pub_date

2008-01-15 00:00:00

pages

600-2

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01388-1

journal_volume

18

pub_type

杂志文章

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