Abstract:
:Developing efficient controlled release system of insecticide can facilitate the better use of insecticide. We described here a first example of photo-controlled release of an insecticide by linking fipronil with photoresponsive coumarin covalently. The generated coumarin-fipronil (CF) precursor could undergo cleavage to release free fipronil in the presence of blue light (420nm) or sunlight. Photophysical studies of CF showed that it exhibited strong fluorescence properties. The CF had no obvious activity against mosquito larvae under dark, but it can be activated by light inside the mosquito larvae. The released Fip from CF by blue light irradiation in vitro retained its activity to armyworm (Mythimna separate) with LC50 value of 24.64μmolL-1. This photocaged molecule provided an alternative delivery method for fipronil.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Gao Z,Yuan P,Wang D,Xu Z,Li Z,Shao Xdoi
10.1016/j.bmcl.2017.03.091subject
Has Abstractpub_date
2017-06-01 00:00:00pages
2528-2535issue
11eissn
0960-894Xissn
1464-3405pii
S0960-894X(17)30353-0journal_volume
27pub_type
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