当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY LETTERS期刊下所有文献 > Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis.

Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis.

Abstract：

:Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (1) and Sch 725739 (2). Compound 1 was identified as the NaV1.8 inhibitor with IC(50) of approximately 9 microM. The purification and the structure elucidation of these two saponins are described.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yang SW,Chan TM,Buevich A,Priestley T,Crona J,Reed J,Wright AE,Patel M,Gullo V,Chen G,Pramanik B,Chu M

doi

10.1016/j.bmcl.2007.08.025

subject

Has Abstract

pub_date

2007-10-15 00:00:00

pages

5543-7

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00974-2

journal_volume

17

pub_type

杂志文章

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