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Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides.

Abstract：

:Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to (31)P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2',3'-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Gerasimova YV,Erchenko IA,Shakirov MM,Godovikova TS

doi

10.1016/j.bmcl.2008.07.060

subject

Has Abstract

pub_date

2008-08-15 00:00:00

pages

4511-4

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00824-X

journal_volume

18

pub_type

杂志文章

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