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Nav1.7 inhibitors for the treatment of chronic pain.

Abstract：

:The voltage gated sodium channel Nav1.7 plays an essential role in the transmission of pain signals. Strong human genetic validation has motivated extensive efforts to discover potent, selective, and efficacious Nav1.7 inhibitors for the treatment of chronic pain. This digest will introduce the structure and function of Nav1.7 and highlight the wealth of recent developments on a diverse array of Nav1.7 inhibitors, including optimization of their potency, selectivity, and PK/PD relationships.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

McKerrall SJ,Sutherlin DP

doi

10.1016/j.bmcl.2018.08.007

subject

Has Abstract

pub_date

2018-10-15 00:00:00

pages

3141-3149

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(18)30670-X

journal_volume

28

pub_type

杂志文章,评审

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