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Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.

Abstract：

:The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the discovery of key compounds 10j and 17h.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ting PC,Lee JF,Zorn N,Kim HM,Aslanian RG,Lin M,Smith M,Walker SS,Cook J,Van Heek M,Lachowicz J

doi

10.1016/j.bmcl.2012.12.040

subject

Has Abstract

pub_date

2013-02-15 00:00:00

pages

985-8

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)01634-4

journal_volume

23

pub_type

杂志文章

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