Abstract:
:Several recent reports have highlighted the feasibility of the use of penfluridol, a well-known antipsychotic agent, as a chemotherapeutic agent. In vivo experiments have confirmed the cytotoxic activity of penfluridol in triple-negative breast cancer model, lung cancer model, and further studies have been proposed to assess its anticancer activity and viability for the treatment of glioblastomas. However, penfluridol anticancer activity was observed at a dosage significantly higher than that administered in antipsychotic therapy, thus raising the concern for the potential onset of CNS side effects in patients undergoing intensive pharmacological treatment. In this study, we evaluate the potential CNS toxicity of penfluridol side by side with a set of analogs.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Ashraf-Uz-Zaman M,Sajib MS,Cucullo L,Mikelis CM,German NAdoi
10.1016/j.bmcl.2018.10.036subject
Has Abstractpub_date
2018-12-15 00:00:00pages
3652-3657issue
23-24eissn
0960-894Xissn
1464-3405pii
S0960-894X(18)30838-2journal_volume
28pub_type
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