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Design and synthesis of beta-carboxamido phosphonates as potent inhibitors of imidazole glycerol phosphate dehydratase.

Abstract：

:We describe the synthesis and enzymatic activity of a library of beta-carboxamido phosphonates as inhibitors of imidazole glycerol phosphate dehydratase (IGPD). Biological results suggest the presence of an enzymatic interaction site not previously observed for other inhibitors of IGPD.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Schweitzer BA,Loida PJ,Thompson-Mize RL,CaJacob CA,Hegde SG

doi

10.1016/s0960-894x(99)00338-8

subject

Has Abstract

pub_date

1999-07-19 00:00:00

pages

2053-8

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960894X99003388

journal_volume

9

pub_type

杂志文章

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