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2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases.

Abstract：

:Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Chen P,Horton LB,Mikulski RL,Deng L,Sundriyal S,Palzkill T,Song Y

doi

10.1016/j.bmcl.2012.08.012

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

6229-32

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)01001-3

journal_volume

22

pub_type

杂志文章

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