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Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists.

Abstract：

:High-throughput screening of the GSK compound collection against the P2Y(1) receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Morales-Ramos AI,Mecom JS,Kiesow TJ,Graybill TL,Brown GD,Aiyar NV,Davenport EA,Kallal LA,Knapp-Reed BA,Li P,Londregan AT,Morrow DM,Senadhi S,Thalji RK,Zhao S,Burns-Kurtis CL,Marino JP Jr

doi

10.1016/j.bmcl.2008.09.102

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

6222-6

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)01175-X

journal_volume

18

pub_type

杂志文章

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