Abstract:
:The novel analysis method consisting of size-exclusion chromatography (SEC) and HRMS analysis was firstly applied in the discovery of potential inhibitors towards cancer drug targets. With vascular endothelial growth factor receptor (VEGFR-2) as a target, dynamic combinatorial libraries (DCLs) were prepared by reacting aldehydes with amines. Four sensitive binders targeted VEGFR-2 were directly isolated from the library. Antitumor activity test in vitro and inhibition experiments toward angiogenesis were also carried out.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Yang Z,Fang Z,He W,Wang Z,Gan H,Tian Q,Guo Kdoi
10.1016/j.bmcl.2016.02.063subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1671-4issue
7eissn
0960-894Xissn
1464-3405pii
S0960-894X(16)30185-8journal_volume
26pub_type
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
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journal_title:Bioorganic & medicinal chemistry letters
pub_type: 杂志文章
doi:10.1016/j.bmcl.2008.04.011
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journal_title:Bioorganic & medicinal chemistry letters
pub_type: 杂志文章
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更新日期:2010-09-15 00:00:00
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journal_title:Bioorganic & medicinal chemistry letters
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