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A graftable LDV peptidomimetic: design, synthesis and application to a blood filtration membrane.

Abstract：

:A graftable LDV (Leu-Asp-Val) peptidomimetic molecule (B-c) has been prepared from 3-(5-amino-2-hydroxy)phenyl-propionic acid, as alpha(4)beta(1) (VLA-4) integrin ligand. For that purpose, the mechanism of 3-(4-azidophenyl)propionic acid rearrangement has been revisited. Activation of Durapore DVPP-hydrophilic membrane, by surface wet chemistry using triazine trifluoride, followed by covalent coupling of B-c produced a modified filter (0.8% of derivatisation from XPS analysis) with improved capacity of leukocyte retention.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Momtaz M,Rerat V,Gharbi S,Gérard E,Pourcelle V,Marchand-Brynaert J

doi

10.1016/j.bmcl.2007.12.006

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

1084-90

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01449-7

journal_volume

18

pub_type

杂志文章

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