Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model.

Abstract:

:Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.

journal_name

Bioorg Med Chem Lett

authors

Matti AA,Mirzaei J,Rudolph J,Smith SA,Newell JL,Patel SA,Braden MR,Bridges RJ,Natale NR

doi

10.1016/j.bmcl.2013.08.080

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

5931-5

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)01020-2

journal_volume

23

pub_type

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