Abstract:
:Microwave accelerated reaction system (MARS) technology provided a good method to obtain selective and open isoxazole ligands that bind to and inhibit the Sxc- antiporter. The MARS provided numerous advantages, including: shorter time, better yield and higher purity of the product. Of the newly synthesized series of isoxazoles the salicyl hydrazide 6 exhibited the highest level of inhibitory activity in the transport assay. A homology model has been developed to summarize the SAR results to date, and provide a working hypothesis for future studies.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Matti AA,Mirzaei J,Rudolph J,Smith SA,Newell JL,Patel SA,Braden MR,Bridges RJ,Natale NRdoi
10.1016/j.bmcl.2013.08.080subject
Has Abstractpub_date
2013-11-01 00:00:00pages
5931-5issue
21eissn
0960-894Xissn
1464-3405pii
S0960-894X(13)01020-2journal_volume
23pub_type
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