Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect.

Abstract:

:A series of 1-(quinoliloxypropyl)-4-aryl-piperazines has been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypic behaviour in mice. The 8-hydroxyquinoline ether derivative 14 has emerged as an important lead compound showing a potential atypical antipsychotic profile. Employing appropriate physicochemical properties, the similarity of the compounds was assessed with respect to some atypical antipsychotic drugs as clozapine, ketanserine, ziprasidone and risperidone.

journal_name

Bioorg Med Chem Lett

authors

Bali A,Malhotra S,Dhir H,Kumar A,Sharma A

doi

10.1016/j.bmcl.2009.04.019

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

3041-4

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00511-3

journal_volume

19

pub_type

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