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Activation of mitogen activated protein kinase (MAPK) during D-galactosamine intoxication in the rat liver.

Abstract：

:A significant increase in plasma glutamate-oxaloacetate transaminase and glutamate-pyruvate transaminase was observed 6 h after intraperitoneal administration of D-galactosamine (D-Galn). Three hours after administration of D-Galn, the vitamin C concentration in the liver decreased significantly compared to that in a control group and thereafter the hepatic vitamin C concentration remained at a significantly lower level. Phosphorylated JNK (c-Jun NH2-terminal kinase) and phosphorylated ERK (extracellular signal-regulated kinase) started increasing 3 h after D-Galn treatment and remained at a high level for 6-12 h after the treatment, while phosphorylated p38 MAPK increased significantly 6 h after D-Galn administration. These results indicated that oxidative stress and the activation of JNK and ERK took place almost simultaneously, followed by the activation of p38 MAPK.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nishioka H,Kishioka T,Iida C,Fujii K,Ichi I,Kojo S

doi

10.1016/j.bmcl.2006.02.057

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

3019-22

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00243-5

journal_volume

16

pub_type

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