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Protective effect of nitronyl nitroxide-amino acid conjugates on liver ischemia-reperfusion induced injury in rats.

Abstract：

:Stable nitroxides are potential antioxidant drugs. In this study, we have linked nitroxide to natural amino acids with the aim to improve therapeutic activity. The radical scavenging activities of two nitronyl nitroxide-amino acid conjugates (NNR and NNK) were evaluated in PC 12 cell survival assays. The NO scavenging activities of these compounds were confirmed in the acetylcholine-induced vasorelaxation assay. In addition, the protective effect of NNR was demonstrated in an in vivo rat model of hepatic ischemia-reperfusion (I/R) induced injury and oxidative change. Because NNR reduced hepatic I/R injury by minimizing oxidative stress, it might be possible to develop it into a possible therapeutic agent for hepatic I/R injury.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Bi W,Cai J,Xue P,Zhang Y,Liu S,Gao X,Li M,Wang Z,Baudy-Floc'h M,Green SA,Bi L

doi

10.1016/j.bmcl.2008.02.030

subject

Has Abstract

pub_date

2008-03-15 00:00:00

pages

1788-94

issue

6

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00211-4

journal_volume

18

pub_type

杂志文章

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