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Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors.

Abstract：

:Aromatase is a target of pharmacological interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory activity against aromatase.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yahiaoui S,Pouget C,Fagnere C,Champavier Y,Habrioux G,Chulia AJ

doi

10.1016/j.bmcl.2004.07.090

subject

Has Abstract

pub_date

2004-10-18 00:00:00

pages

5215-8

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(04)00991-6

journal_volume

14

pub_type

杂志文章

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