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Tri-substituted acylhydrazines as tertiary amide bioisosteres: HCV NS5B polymerase inhibitors.

Abstract：

:The use of a tri-substituted acylhydrazine as an isostere of a tertiary amide was explored in a series of HCV NS5B thumb site II inhibitors. Direct replacement generated an analog with similar conformational and physicochemical properties. The series was extended to produce compounds with potent binding affinities and encouraging levels of cellular potency.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Canales E,Carlson JS,Appleby T,Fenaux M,Lee J,Tian Y,Tirunagari N,Wong M,Watkins WJ

doi

10.1016/j.bmcl.2012.05.025

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

4288-92

issue

13

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00628-2

journal_volume

22

pub_type

杂志文章

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