Abstract:
:A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel-Michael reaction of 3-cyanoacetyl indole, various aromatic aldehydes and malononitrile catalyzed by InCl(3) in ethanol under reflux conditions. The newly synthesized 3-pyranyl indoles were evaluated for anti-microbial, antioxidant, and anticancer activities. Some of the compounds showed good anticancer activity against MCF-7 breast cancer cell lines on comparison with of standard drug.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Lakshmi NV,Thirumurugan P,Noorulla KM,Perumal PTdoi
10.1016/j.bmcl.2010.07.039subject
Has Abstractpub_date
2010-09-01 00:00:00pages
5054-61issue
17eissn
0960-894Xissn
1464-3405pii
S0960-894X(10)00995-9journal_volume
20pub_type
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